septic shock

Glucocorticoid therapy may be beneficial to patients who have severe septic shock (defined as a systolic blood pressure ＜90 mmHg for more than one hour despite adequate fluid resuscitation plus vasopressor administration).
There are no high or moderate quality data to suggest that glucocorticoid therapy is beneficial to patients with less severe septic shock. (See "Clinical evidence" above).
Classification of adrenal reserve as adequate or inadequate fails to identify patients who are more likely to benefit from glucocorticoid therapy. (See "Clinical evidence" above).

We typically administer 50 mg of hydrocortisone every six hours or 100 mg of hydrocortisone every eight hours.